Atis Elsts (currently at University of Bristol) Agris Pentjuss and Egils Stalidzans have created a wrapper software for the software COPASI (http://copasi.org/) for automatic execution of optimal adjustable parameter combination search in metabolic engineering tasks. The software is published in the journal Bioinformatics (Oxford), IF=7,3.
Reference:
Elsts, A., Pentjuss, A., Stalidzans, E. (2017) SpaceScanner: COPASI wrapper for automated management of global stochastic optimization experiments. Bioinformatics Vol. 33, p.2966-2967. doi:10.1093/bioinformatics/btx363