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Basic Sciences of Medicine including Pharmacy

Medical biochemistry

Detection of DNA damage

Studies of DNA damage in cell cultures or animal tissues using single cell electrophoresis (comet assay). Oxidised bases can also be detected using combinations of comet assays and enzyme treatments.

 

Nikolajs Sjakste
(nikolajs.sjakste@lu.lv; +371 29198804; https://www.mf.lu.lv/)

Interaction of DNA wih small organic molecules

Studies on the interaction of DNA with small organic molecules. Spectrophotometry, spectrofluorimetry, circular dichroism and cyclic voltammetry can be used.

 Nikolajs Sjakste
(nikolajs.sjakste@lu.lv; +371 29198804; https://www.mf.lu.lv/)

Genome polymorphisms

Sequence-specific PCR, restriction analysis and other methods for detection of genome polyformis.

 Nikolajs Sjakste
(nikolajs.sjakste@lu.lv; +371 29198804; https://www.mf.lu.lv/)